Spansules are one of the most advanced and modified form of drug delivery system. Spansules gives one of the best methods to deliver multiple drugs at one time. Since the spansules have different coating thickness, they release drug at different manner. The entrance of the spansules into the small intestine (where the majority of drug absorption occurs) is usually more uniform than with non-disintegrating sustained-release tablet formulations. In case of controlled release spansules the onset of absorption is less sensitive to stomach emptying and reduces the rate of rise of drug concentration in blood and enhanced bioavailability. Spansules increases the safety margin of high potency drugs and reduces the incidence of both systemic and local side effects in sensitive patients. Spansules reduces the dosing frequency, improved patient compliance and reduce side effects. Spansules provide both controlled and sustained release for single or multiple prescriptions and over the counter medicine. Present review discussed on the spansules as one of the novel dosage form, various pharmaceutical advantages of spansules over conventional dosage forms, different evaluation parameters of spansules and available marketed preparations of spansules. The controlled drug delivery system is become the fastest growing field in pharmaceutical dosage forms and acquiring dominance in market. So many product in market are in available in spansules capsules dosage form. Due to many advantages possessed by spansules the pharmaceutical industry are now focusing more over its research and development and formulation.
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